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Sci Pract Perspect. 2002 Jul;1(1):13-20.

The neurobiology of opioid dependence: implications for treatment.

Author information

1
Yale University School of Medicine, New Haven, Connecticut, USA. thomas.kosten@yale.edu

Abstract

Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser's struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments.

PMID:
18567959
PMCID:
PMC2851054
[Indexed for MEDLINE]
Free PMC Article
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