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Science. 2008 Jun 20;320(5883):1651-4. doi: 10.1126/science.1158160.

Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors.

Author information

1
Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

Abstract

Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.

PMID:
18566289
PMCID:
PMC2514061
DOI:
10.1126/science.1158160
[Indexed for MEDLINE]
Free PMC Article

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