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Cell Mol Life Sci. 2008 Oct;65(19):3058-73. doi: 10.1007/s00018-008-8122-2.

Structure and dynamic regulation of Src-family kinases.

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Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, 02115, USA.


Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.

[Indexed for MEDLINE]

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