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J Biomed Inform. 2008 Oct;41(5):779-89. doi: 10.1016/j.jbi.2008.05.001. Epub 2008 May 11.

yOWL: an ontology-driven knowledge base for yeast biologists.

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1
School of Computer Science, Carleton University, Ottawa, Ont., Canada K1S5B6.

Abstract

Knowledge management is an ongoing challenge for the biological community such that large, diverse and continuously growing information requires more sophisticated methods to store, integrate and query their knowledge. The semantic web initiative provides a new knowledge engineering framework to represent, share and discover information. In this paper, we describe our efforts towards the development of an ontology-based knowledge base, including aspects from ontology design and population using "semantic" data mashup, to automated reasoning and semantic query answering. Based on yeast data obtained from the Saccharomyces Genome Database and UniProt, we discuss the challenges encountered during the building of the knowledge base and how they were overcome.

PMID:
18562252
DOI:
10.1016/j.jbi.2008.05.001
[Indexed for MEDLINE]
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