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Dev Biol. 2008 Aug 1;320(1):30-8. doi: 10.1016/j.ydbio.2008.03.038. Epub 2008 Apr 9.

Branch architecture of the fly larval abdominal serotonergic neurons.

Author information

1
Department of Biology, University of Virginia, Gilmer Hall 071 Box 400328, Charlottesville, VA 22903, USA.

Abstract

In the metazoan central nervous system (CNS), serotonergic neurons send projections throughout the synaptic neuropil. Little is known about the rules that govern these widespread neuromodulatory branching patterns. In this study, we utilize the Drosophila as a model to examine serotonergic branching. Using single cell GFP labeling we show that within each segment of the Drosophila ventral nerve cord (VNC), each of two serotonergic neurons tiles distinct innervation patterns in the contralateral neuropil. In addition, branches extend only a short distance from the target segment. Through ablation-mediated isolation of serotonergic cells, we demonstrate that the distinct areas of innervation are not maintained through competition between neighboring like-serotonergic neurites. Furthermore, the basic branching pattern of serotonergic neurons within the neuropil remains unchanged despite alterations of initial axonal trajectories.

PMID:
18561908
PMCID:
PMC2610461
DOI:
10.1016/j.ydbio.2008.03.038
[Indexed for MEDLINE]
Free PMC Article

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