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Arch Otolaryngol Head Neck Surg. 2008 Jun;134(6):621-4. doi: 10.1001/archotol.134.6.621.

Correlation of olfactory function with changes in the volume of the human olfactory bulb.

Author information

1
Department of Neurology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany.

Abstract

OBJECTIVE:

To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function.

DESIGN:

Prospective, before-after trial.

SETTING:

Outpatient clinic of a university clinic for otorhinolaryngology.

PATIENTS:

A total of 20 patients with olfactory loss participated in the study. The duration of olfactory deficits ranged from 3 months to 6 years.

MAIN OUTCOME MEASURES:

Olfactory function was assessed for phenyl ethyl alcohol odor threshold, odor discrimination, and odor identification. Olfactory bulb volume was determined using magnetic resonance imaging.

RESULTS:

In initially hyposmic patients (n = 13), changes in OB volume were found to correlate with odor threshold changes (r = 0.82; P = .001); no such correlation was found for odor discrimination or odor identification.

CONCLUSION:

As demonstrated in a longitudinal study for the first time to our knowledge, the human OB is a highly plastic structure that responds to individual changes in olfactory status.

PMID:
18559729
DOI:
10.1001/archotol.134.6.621
[Indexed for MEDLINE]

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