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Chem Biol. 2008 Jun;15(6):523-4. doi: 10.1016/j.chembiol.2008.06.001.

Geometry shapes cell signaling network output.

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1
University of Connecticut Health Center, Center for Cell Analysis and Modeling, Farmington, CT 06032-1507, USA. rholmes@uchc.edu

Abstract

Through live cell imaging and computational modeling, Neves et al. (2008) demonstrate that molecular interactions alone are insufficient to explain the patterns of MAPK activation: a model must include the cell morphology and spatial distribution of signaling molecules.

PMID:
18559261
DOI:
10.1016/j.chembiol.2008.06.001
[Indexed for MEDLINE]
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