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J Am Soc Echocardiogr. 2008 Oct;21(10):1105-8. doi: 10.1016/j.echo.2008.05.004. Epub 2008 Jun 16.

Initial fetal cardiovascular profile score predicts recipient twin outcome in twin-twin transfusion syndrome.

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  • 1Fetal Care Center of Cincinnati, Divisions of Pediatric Cardiology, General, Thoracic, and Fetal Surgery, Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.



The aim of this study was to assess the relationship between cardiomyopathy and recipient twin (RT) outcome in twin-twin transfusion syndrome (TTTS).


Fetal echocardiography and outcomes data in 62 consecutive pregnancies with TTTS were reviewed. The primary outcome was neonatal RT survival. The severity of RT cardiomyopathy at presentation was assessed by the cardiovascular profile score (CVPS). RT outcomes and odds of survival were compared between groups stratified by CVPS.


Overall neonatal survival for all fetuses was 61% (76 of 124). RT survival was 58% (36 of 62). Grouped by CVPS, RT survival was greater (50%) for those with CVPS > or = 9 and even higher (74%) for CVPS of 10. Among the components of the CVPS, atrioventricular valve regurgitation was associated with negative RT outcome. Other factors at presentation were not predictive of RT outcome.


A normal CVPS in the RT in TTTS is predictive of improved survival compared with an abnormal CVPS, even in RTs with minor deductions. Standard clinical staging did not predict outcome. Cardiac assessment by CVPS may improve clinical decision making and the timing of fetal interventions.

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