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Anal Chim Acta. 2008 Jul 14;620(1-2):8-26. doi: 10.1016/j.aca.2008.05.022. Epub 2008 May 18.

Sensitive optical biosensors for unlabeled targets: a review.

Author information

1
Department of Biological Engineering, University of Missouri, 240D, Bond Life Sciences Center, 1201 E. Rollins Street, Columbia, Missouri 65211, USA. fanxud@missouri.edu

Abstract

This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms. In particular, it will focus on the optical biosensors that utilize the refractive index change as the sensing transduction signal. Various optical label-free biosensing platforms will be introduced, including, but not limited to, surface plasmon resonance, interferometers, waveguides, fiber gratings, ring resonators, and photonic crystals. Emphasis will be given to the description of optical structures and their respective sensing mechanisms. Examples of detecting various types of biomolecules will be presented. Wherever possible, the sensing performance of each optical structure will be evaluated and compared in terms of sensitivity and detection limit.

PMID:
18558119
DOI:
10.1016/j.aca.2008.05.022
[Indexed for MEDLINE]

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