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J Antimicrob Chemother. 2008 Sep;62(3):431-3. doi: 10.1093/jac/dkn240. Epub 2008 Jun 12.

Interventions to control MRSA: high time for time-series analysis?

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1
Infection Control Program, University of Geneva Hospitals and Medical School, CH-1211 Geneva 14, Switzerland. stephan.harbarth@hcuge.ch

Abstract

Time-series methods are useful in quasi-experimental study designs in which rates of antibiotic-resistant infections are ascertained before and after an intervention. However, uncertainties remain regarding the use of time-series analysis as an appropriate research methodology for analysing the effect of infection control interventions and antibiotic policies on the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA). In particular, there is still a substantial gap in our understanding of what actually happens to MRSA incidence when a planned intervention is made on use of one or more antibiotic drug classes.

PMID:
18556707
DOI:
10.1093/jac/dkn240
[Indexed for MEDLINE]
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