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Curr Opin Struct Biol. 2008 Aug;18(4):477-83. doi: 10.1016/j.sbi.2008.04.008. Epub 2008 Jun 12.

Structural specificity in coiled-coil interactions.

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1
MIT Department of Biology, Cambridge, MA 02139, United States.

Abstract

Coiled coils have a rich history in the field of protein design and engineering. Novel structures, such as the first seven-helix coiled coil, continue to provide surprises and insights. Large-scale datasets quantifying the influence of systematic mutations on coiled-coil stability are a valuable new asset to the area. Scoring methods based on sequence and/or structure can predict interaction preferences in coiled-coil-mediated bZIP transcription factor dimerization. Experimental and computational methods for dealing with the near-degeneracy of many coiled-coil structures appear promising for future design applications.

PMID:
18555680
PMCID:
PMC2567808
DOI:
10.1016/j.sbi.2008.04.008
[Indexed for MEDLINE]
Free PMC Article
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