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Psychiatry Res. 2008 Aug 15;160(2):145-54. doi: 10.1016/j.psychres.2007.11.019. Epub 2008 Jun 13.

Attentional deficits in cocaine-dependent patients: converging behavioral and electrophysiological evidence.

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  • 1University of Wisconsin-Madison, Departments of Psychology and Psychiatry, 1202 West Johnson Street, Madison, WI 53706, USA.


Although there are several reports of patients with cocaine dependence displaying cognitive deficits, the nature of their information processing deficits is not well characterized. In the present study, the attentional performance of cocaine-dependent patients (n=14) was examined and compared with that of healthy control individuals (n=15). Attention was assessed using an auditory oddball event-related task as well as the Continuous Performance Test (CPT, Identical Pairs version). The cocaine-dependent group displayed P300 amplitude reduction compared to controls. The group difference in P300 response latency did not reach significance. On the CPT, the cocaine-dependent patients displayed significantly poorer discriminability and greater errors of commission than the controls. There was a positive correlation between performance on the oddball event-related task and performance on the CPT. This investigation provides converging behavioral and electrophysiological evidence of attentional deficits in cocaine-dependent patients.

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