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FEBS Lett. 2008 Jul 9;582(16):2441-4. doi: 10.1016/j.febslet.2008.06.008. Epub 2008 Jun 12.

Prediction of replication time zones at single nucleotide resolution in the human genome.

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Department of Physics, Tianjin University, Tianjin 300072, China.


The human genome is structured at multiple levels: it is organized into a series of replication time zones, and meanwhile it is composed of isochores. Accumulating evidence suggests a match between these two genome features. Based on newly developed software GC-Profile, we obtained a complete coverage of the human genome by 3198 isochores with boundaries at single nucleotide resolution. Interestingly, the experimentally confirmed replication timing sites in the regions of 1p36.1, 6p21.32, 17q11.2 and 22q12.1 nearly all coincide with the determined isochore boundaries. The precise boundaries of the 3198 isochores are available via the website:

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