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Fertil Steril. 2009 Apr;91(4 Suppl):1351-4. doi: 10.1016/j.fertnstert.2008.03.043. Epub 2008 Jun 12.

Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.

Author information

  • 1Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA. bchen@stanford.edu

Abstract

We investigated the effect of relaxin on extracellular matrix remodeling in cultured myometrial compared with leiomyoma smooth muscle cells. Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells.

PMID:
18554597
PMCID:
PMC2728012
DOI:
10.1016/j.fertnstert.2008.03.043
[PubMed - indexed for MEDLINE]
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