Format

Send to

Choose Destination
See comment in PubMed Commons below
Eplasty. 2008 May 16;8:e27.

Smoke inhalation lung injury: an update.

Author information

1
Harvard Medical School, Burn and Trauma Center, Brigham and Women's Hospital, Boston, MA, USA. rhdemling@partners.org

Abstract

OBJECTIVES:

The purpose of this study is to present a multifaceted, definitive review of the past and current status of smoke inhalation injury. History along with current understanding of anatomical, physiology, and biologic components will be discussed.

METHODS:

The literature has been reviewed from the early onset of the concept of smoke inhalation in the 1920s to our current understanding as of 2007.

RESULTS:

The results indicate that the current pathophysiologic concept is of a disease process that leads to immediate and delayed pulmonary injury best managed by aggressive physiologic support. Management approaches for the biochemical changes have not kept up with current knowledge. The lung injury process is activated by toxins in the smoke's gas and particle components and perpetuated by a resulting lung inflammation. This inflammatory process becomes self-perpetuating through the activation of a large number of inflammatory cascades. In addition, smoke injury leads to significant systemic abnormalities injuring other organs and accentuating the burn injury process and subsequently leading to mediator-induced cellular injury leading potentially to multisystem organ failure.

CONCLUSIONS:

Smoke inhalation injury results in the anatomic finding of denuded and sometimes sloughed airways mucosa. Physiologic findings include small airways containing fibrin casts of mucosa and neutrophils. Airway hyper-reactivity results as well, leading to further decreased collapse, causing obstruction.

PMID:
18552974
PMCID:
PMC2396464
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center