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Nat Neurosci. 2008 Jul;11(7):752-3. doi: 10.1038/nn.2139. Epub 2008 Jun 15.

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

Author information

1
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.

Abstract

We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.

PMID:
18552842
PMCID:
PMC2765052
DOI:
10.1038/nn.2139
[Indexed for MEDLINE]
Free PMC Article

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