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Pharmacol Rev. 2008 Jun;60(2):143-5. doi: 10.1124/pr.108.00372. Epub 2008 Jun 13.

International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor.

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School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.


Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2). After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term "CGRP(2)" receptor should no longer be used, and the "CGRP(1)" receptor should be known as the "CGRP" receptor.

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