Format

Send to

Choose Destination
Adicciones. 2008;20(2):171-83.

[Cannabinoid system and feeding regulation].

[Article in Spanish]

Author information

1
Unidad de Psiquiatría. Fundación Hospital Alcorcón. 28922 Alcorcón (Madrid). farias@fhalcorcon.es

Abstract

There is increasing evidence to suggest that the cannabinoid system is a crucial mechanism in the regulation of feeding and metabolism. It is against this background that a cannabinoid antagonist, rimonabant, is about to come onto the market for the treatment of obesity. Moreover, in addition to weight-loss effect, this drug has a beneficial effect on the so-called metabolic syndrome, with changes in the lipid and glucidic metabolism not observed for other anti-obesity drugs currently available. We present a review of current knowledge in this field and data from our own studies: genetic studies of this system in eating disorders and in obesity and studies of localization of cannabinoid receptors at sites related to feeding. These studies support a state of cannabinoid hyperactivity in obesity; furthermore, such hyperactivity can constitute a prognostic factor.

PMID:
18551230
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Socidrogalcohol
Loading ...
Support Center