The purpose of this paper is to propose a research agenda for the measurement of economic impacts of Canadian government R&D support programs. Different methodologies and indicators used to assess benefits from government support programs/agencies for R&D are discussed first. Using available information on major business-related R&D federal programs, the paper will assess which indicators and methodologies can be implemented. The specific programs/agencies under investigation include: Technology Partnerships Canada sponsored by Industry Canada, Industrial Research Assistance Program sponsored by National Research Council, Atlantic Innovation Fund sponsored by Atlantic Canada Opportunities Agency, Canadian Space Agency and National Defence.