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Immunity. 2008 Jun;28(6):735-9. doi: 10.1016/j.immuni.2008.05.005.

Regulation of mitochondrial antiviral signaling pathways.

Author information

  • 1Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. cbmoore2@med.unc.edu

Abstract

Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.

PMID:
18549796
DOI:
10.1016/j.immuni.2008.05.005
[PubMed - indexed for MEDLINE]
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