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Expert Opin Investig Drugs. 2008 Jul;17(7):997-1011. doi: 10.1517/13543784.17.7.997 .

Targeting the c-MET signaling pathway for cancer therapy.

Author information

1
Incyte Corporation, Experimental Station, Rt. 141 & Henry Clay Road, Wilmington, DE 19880, USA. xliu@incyte.com

Abstract

BACKGROUND:

In many human cancers, c-MET is activated via receptor overexpression, amplification, mutation and/or a ligand-dependent autocrine/paracrine loop. These biochemical and genetic abnormalities have been correlated with poor clinical outcomes and drug resistance in cancer patients. Preclinical studies suggest that targeting aberrant c-MET signaling could be an attractive therapy in cancer, but this notion has only recently been tested in the clinic.

OBJECTIVES:

To describe the biological aspects of the c-MET signaling pathway and to discuss recent progress and possible future trends in the development of agents that target the c-MET pathway, with an emphasis on small-molecule c-MET kinase inhibitors.

METHOD:

A review of relevant publications, including published articles in literature, reports at scientific meetings, and information available through the Internet.

RESULTS/CONCLUSION:

The dysregulated c-MET pathway represents a promising target for cancer drug development. The agents that target the c-MET pathway have demonstrated impressive evidence of early clinical activity and may have a significant therapeutic potential.

PMID:
18549337
DOI:
10.1517/13543784.17.7.997
[Indexed for MEDLINE]

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