Format

Send to

Choose Destination
See comment in PubMed Commons below
Org Lett. 2008 Jul 17;10(14):3153-6. doi: 10.1021/ol801066y. Epub 2008 Jun 13.

Asymmetric total synthesis of botcinins C, D, and F.

Author information

1
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan.

Abstract

Stereoselective total synthesis of botcinins C, D, and F is effectively carried out through asymmetric aldol reactions, 6-endo ring closure, and SmI2-mediated 3,4-trans or -cis stereoselective intramolecular Reformatsky reaction. Rapid esterification of the main skeleton of botcinins with the chiral side chain using MNBA and DMAP produced botcinin D, an antifungal chemical against a pathogen of rice blast disease.

PMID:
18549237
DOI:
10.1021/ol801066y
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center