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Biomaterials. 1991 Apr;12(3):281-6.

Wound management with N-carboxybutyl chitosan.

Author information

1
Institute of Human Morphology, Faculty of Medicine, University of Ancona, Italy.

Abstract

In patients undergoing plastic surgery, donor sites were treated with soft pads of freeze-dried N-carboxybutyl chitosan to promote ordered tissue regeneration. Compared to control donor sites, better histoarchitectural order, better vascularization and the absence of inflammatory cells were observed at the dermal level, whilst fewer aspects of proliferation of the malpighian layer were reported at the epidermal level. Accordingly, N-carboxybutyl chitosan leads to formation of regularly organized cutaneous tissue and reduces anomalous healing.

PMID:
1854896
DOI:
10.1016/0142-9612(91)90035-9
[Indexed for MEDLINE]

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