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Bioorg Med Chem Lett. 2008 Jul 15;18(14):4249-52. doi: 10.1016/j.bmcl.2008.02.020. Epub 2008 Feb 10.

Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length.

Author information

1
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.

Abstract

A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG.

PMID:
18547804
DOI:
10.1016/j.bmcl.2008.02.020
[Indexed for MEDLINE]

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