Format

Send to

Choose Destination
Adv Exp Med Biol. 2008;622:273-80. doi: 10.1007/978-0-387-68969-2_22.

Role of vascular leukocytes in ovarian cancer neovascularization.

Author information

1
Center for Research on the Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia 19104, USA.

Abstract

Vascular leukocytes are a unique population of CD45+ VE-cadherin+ cells with diverse functions. VLCs are capable of antigen presentation, as well as formation of endothelial-like structures in vitro and in vivo. VLCs are largely present among CD45+ cells infiltrating human ovarian carcinomas and are highly represented in the beta-defensin-VEGF-ID8 syngenic mouse model. Vascular leukocytes are a new and promising novel therapeutic target for anti-angiogenic therapy. Their unique mechanism merits thorough and extensive exploration in the future.

PMID:
18546635
DOI:
10.1007/978-0-387-68969-2_22
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center