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Ann Nutr Metab. 2008;52(3):188-95. doi: 10.1159/000138122. Epub 2008 Jun 11.

Variation of postprandial PYY 3-36 response following ingestion of differing macronutrient meals in obese females.

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Department of Nutrition and Food Science, Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut, Lebanon.



This study investigated the effect of macronutrient composition of meals on postprandial peptide YY(3-36) (PYY(3-36)) response in obese hyperinsulinemic females.


Eight obese females consumed three iso-energetic meals of different macronutrient composition, high carbohydrate (HC; 60% CHO, 20% protein, 20% fat), high fat (HF; 30% CHO, 20% protein, 50% fat) and high protein (HP; 30% CHO, 50% protein, 20% fat), on three separate occasions, 1 month apart. PYY(3-36), insulin and glucose were measured before and 15, 30, 60, 120 and 180 min following each meal.


PYY(3-36) levels increased significantly following the three meals, with the HC meal resulting in a sustained postprandial increase in PYY(3-36) level throughout the experimental period. Comparing the three meals, the HF meal induced a significantly higher increase in postprandial PYY(3-36) levels, at 15 and 30 min as compared to the HP meal (p < 0.05), whereas the postprandial increase following the HP meal became significantly higher than that following the HF meal at 120 min. Postprandial increase in PYY(3-36) was highest in the first hour following the HF meal, while that following the HP meal was delayed by 1 h.


Increasing both protein and fat content of a meal may induce an immediate and prolonged increase in PYY(3-36), resulting in increased satiety and its maintenance for a longer period of time.

[Indexed for MEDLINE]

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