Format

Send to

Choose Destination
See comment in PubMed Commons below
Pathobiology. 2008;75(2):75-84. doi: 10.1159/000123845. Epub 2008 Jun 10.

Cancer stem cells in breast: current opinion and future challenges.

Author information

1
Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Marseille, France. jauffrete@marseille.fnclcc.fr

Abstract

There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular subcomponent that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative.

PMID:
18544962
PMCID:
PMC2789397
DOI:
10.1159/000123845
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Support Center