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J Cutan Med Surg. 2008 May-Jun;12(3):97-101.

Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head.

Author information

1
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada. jason@vancouverskin.com

Abstract

BACKGROUND:

Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy.

OBJECTIVE:

To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application.

METHODS:

Imiquimod 5% cream was administered three times per week for 4 weeks followed by 4 weeks of rest (cycle 1) to AK lesions on the head. If AK lesions remained visible at the end of cycle 1, a second treatment cycle was instituted.

RESULTS:

Fifty percent (30 of 60) of patients experienced complete clearance of AK lesions, and 75% (30 of 40) of patients experienced partial clearance of AK lesions after imiquimod treatment at the end of cycle 2. Moreover, 77% of patients who achieved complete clearance had no visible AK lesions 12 weeks post-treatment. Imiquimod was well tolerated.

CONCLUSION:

Imiquimod cycle therapy may be a safe and effective treatment option for AK lesions.

PMID:
18544290
DOI:
10.2310/7750.2008.07045
[Indexed for MEDLINE]

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