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J Infect Dis. 2008 Aug 1;198(3):318-23. doi: 10.1086/589714.

Oropharyngeal shedding of Epstein-Barr virus in the absence of circulating B cells.

Author information

1
Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

Infection with Epstein-Barr virus (EBV) results in lifelong infection of B cells in the peripheral blood and in episodic shedding of virus from the oropharynx. We monitored patients treated with rituximab (anti-CD20 monoclonal antibody) and found that several had both no detectable B cells and no EBV in the blood but shed EBV from the throat. Although some models postulate that EBV traffics from the B cells in the blood to the throat, where it is subsequently shed, our findings indicate that circulating EBV in B cells is not necessary for the virus to persist in, and to be shed from, the oropharynx.

PMID:
18544038
PMCID:
PMC2679674
DOI:
10.1086/589714
[Indexed for MEDLINE]
Free PMC Article

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