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Methods Mol Biol. 2008;426:145-59. doi: 10.1007/978-1-60327-058-8_8.

Protein structure modeling with MODELLER.

Author information

1
Department of Biopharmaceutical Sciences and California Institute for Quantitative Biomedical Research, University of California at San Francisco, San Francisco, CA, USA.

Abstract

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protocols (correction of protcols) has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

PMID:
18542861
DOI:
10.1007/978-1-60327-058-8_8
[Indexed for MEDLINE]

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