Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Genet. 2008 Jul;9(7):516-26. doi: 10.1038/nrg2395. Epub 2008 Jun 10.

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis.

Author information

1
Department of Neurology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0435, USA. jorge.oksenberg@ucsf.edu

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause of neurological disability in young adults. The modest heritability of MS reflects complex genetic effects and multifaceted gene-environment interactions. The human leukocyte antigen (HLA) region is the strongest susceptibility locus for MS, but a genome-wide association study recently identified new susceptibility genes. Progress in high-throughput genotyping and sequencing technologies and a better understanding of the structural organization of the human genome, together with powerful brain-imaging techniques that refine the phenotype, suggest that the tools could finally exist to identify the full set of genes influencing the pathogenesis of MS.

PMID:
18542080
DOI:
10.1038/nrg2395
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center