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Antimicrob Agents Chemother. 2008 Aug;52(8):2915-8. doi: 10.1128/AAC.00461-08. Epub 2008 Jun 9.

Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.

Author information

1
Division of Pharmacology and Drug Discovery, Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.

Abstract

Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.

PMID:
18541727
PMCID:
PMC2493126
DOI:
10.1128/AAC.00461-08
[Indexed for MEDLINE]
Free PMC Article

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