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Am J Clin Nutr. 2008 Jun;87(6):2003S-9S.

n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects.

Author information

1
Department of Pediatrics, Institute of Human Nutrition, College of Physicians and Surgeons of Columbia University, and Scientiae, LLC, New York, NY 10032, USA.

Abstract

Dietary n-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of n-3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of n-3 fatty acids may be attributed to a number of distinct biological effects on lipid and lipoprotein metabolism, blood pressure, platelet function, arterial cholesterol delivery, vascular function, and inflammatory responses.

PMID:
18541602
DOI:
10.1093/ajcn/87.6.2003S
[Indexed for MEDLINE]

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