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J Bacteriol. 2008 Aug;190(15):5526-30. doi: 10.1128/JB.00558-08. Epub 2008 Jun 6.

Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts.

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1
Department of Genetics, MC5120, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.

PMID:
18539734
PMCID:
PMC2493247
DOI:
10.1128/JB.00558-08
[Indexed for MEDLINE]
Free PMC Article
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