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Dev Cell. 2008 Jun;14(6):815-6. doi: 10.1016/j.devcel.2008.05.011.

Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor.

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1
Institute of Biomedical Research, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK.

Abstract

MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor MYB (or c-Myb).

PMID:
18539110
DOI:
10.1016/j.devcel.2008.05.011
[Indexed for MEDLINE]
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