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Auton Neurosci. 2008 Aug 18;141(1-2):1-9. doi: 10.1016/j.autneu.2008.03.008. Epub 2008 Jun 6.

Peripheral projections of NESP55 containing neurons in the rat sympathetic ganglia.

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Department of Anatomy and Cell Biology, Institute of Biomedicine, Göteborg University, Box 420, SE-405 30 Göteborg, Sweden.


The peripheral projections of neurons expressing neuroendocrine secretory protein 55 (NESP55), a novel member of the chromogranin family, were studied by retrograde tracing technique. It was found that NESP55 positive neurons in the rat superior cervical ganglion projected to a number of targets including the submandibular gland, the cervical lymph nodes, the forehead skin, the iris, but not to the thyroid. Among these NESP55 positive target-projecting neurons, a subpopulation contained neuropeptide Y (NPY), a vasoconstrictor. Forepaw pad projecting neurons were found exclusively in the stellate ganglion, almost all of which (approximately 90%) were immunoreactive to NESP55. Colocalization of NESP55 and calcitonin gene-related peptide (CGRP), a peptide involved in sudomotor effects, was observed in a subpopulation of these paw pad projecting neurons, as was colocalization of NESP55 and NPY. The data suggest that NESP55 may have a functional role in some populations of sympathetic neurons.

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