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Mol Cell. 2008 Jun 6;30(5):539-40. doi: 10.1016/j.molcel.2008.05.010.

SUMO takes control of a ubiquitin-specific protease.

Author information

1
Structural Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA.

Abstract

In this issue of Molecular Cell, Meulmeester et al. (2008) identify USP25 as a SUMO2/3-interacting protein and substrate. A USP25 SUMO interaction motif directs SUMO2/3 specificity, and SUMO modification diminishes USP25's ability to bind and degrade polyubiquitin chains.

PMID:
18538649
PMCID:
PMC2753972
DOI:
10.1016/j.molcel.2008.05.010
[Indexed for MEDLINE]
Free PMC Article

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