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J Proteome Res. 2008 Jul;7(7):3028-34. doi: 10.1021/pr700795f. Epub 2008 Jun 7.

A shotgun proteomic method for the identification of membrane-embedded proteins and peptides.

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  • 1Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

Abstract

Integral membrane proteins perform crucial cellular functions and are the targets for the majority of pharmaceutical agents. However, the hydrophobic nature of their membrane-embedded domains makes them difficult to work with. Here, we describe a shotgun proteomic method for the high-throughput analysis of the membrane-embedded transmembrane domains of integral membrane proteins which extends the depth of coverage of the membrane proteome.

PMID:
18537282
PMCID:
PMC2765231
DOI:
10.1021/pr700795f
[PubMed - indexed for MEDLINE]
Free PMC Article
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