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Dement Geriatr Cogn Disord. 2008;25(6):553-8. doi: 10.1159/000137534. Epub 2008 Jun 9.

Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic.

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1
Memory Clinic, Section 6702, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Abstract

AIM:

Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic.

METHODS:

147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results.

RESULTS:

When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity.

CONCLUSION:

In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease.

PMID:
18536519
DOI:
10.1159/000137534
[Indexed for MEDLINE]
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