Format

Send to

Choose Destination
Bioessays. 2008 Jul;30(7):683-91. doi: 10.1002/bies.20771.

Alternative translation start sites and hidden coding potential of eukaryotic mRNAs.

Author information

1
Institute of Cytology and Genetics, Novosibirsk, Russia. ak@bionet.nsc.ru

Abstract

It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative translation is growing rapidly. Also, the frequent occurrence of alternative translation events and their functional significance are supported by the results of computational evaluations. The functional role of alternative translation and its contribution to eukaryotic proteome complexity are discussed.

PMID:
18536038
DOI:
10.1002/bies.20771
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center