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J Biomater Sci Polym Ed. 2008;19(6):725-53. doi: 10.1163/156856208784522092.

Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues.

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Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2.


This review of current DNA and protein microarray diagnostic and bio-analytical technologies focuses on the different surface chemistries used in these miniaturized surface-capture formats. Description of current strategies in bio-immobilization and coupling to create multiplexed affinity bioassays in micrometer-sized printed spots, problems with current formats and review of some detection methods are included. Recommendations for improving long-standing challenges in DNA- and protein-based arrays are forwarded. The biomaterials community can contribute relevant expertise to these formidable bio-interfacial problems that represent significant barriers to clinical implementation of microarray assays.

[Indexed for MEDLINE]

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