Format

Send to

Choose Destination
J Biomater Sci Polym Ed. 2008;19(6):725-53. doi: 10.1163/156856208784522092.

Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues.

Author information

1
Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2.

Abstract

This review of current DNA and protein microarray diagnostic and bio-analytical technologies focuses on the different surface chemistries used in these miniaturized surface-capture formats. Description of current strategies in bio-immobilization and coupling to create multiplexed affinity bioassays in micrometer-sized printed spots, problems with current formats and review of some detection methods are included. Recommendations for improving long-standing challenges in DNA- and protein-based arrays are forwarded. The biomaterials community can contribute relevant expertise to these formidable bio-interfacial problems that represent significant barriers to clinical implementation of microarray assays.

PMID:
18534094
DOI:
10.1163/156856208784522092
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center