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J Clin Psychiatry. 2008;69 Suppl 4:15-20.

Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders.

Author information

1
Department of Psychiatry, Indiana University School of Medicine, Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202-4800, USA. cmcdougl@iupui.edu

Abstract

Atypical antipsychotics are emerging as the first-line pharmacologic treatment for irritability (i.e., aggression, self-injurious behavior, and severe tantrums) in children and adolescents with autistic and other pervasive developmental disorders. Results from placebo-controlled and open-label studies of clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole in this subject population are reviewed. Additional placebo-controlled trials and studies of longer-term safety and tolerability are needed.

PMID:
18533764
[Indexed for MEDLINE]
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