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J Am Chem Soc. 2008 Jul 2;130(26):8142-3. doi: 10.1021/ja8019643. Epub 2008 Jun 5.

Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis.

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1
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.

Abstract

We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the 10-membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of enediyne biosynthesis starts at the PKS stage.

PMID:
18529057
DOI:
10.1021/ja8019643
[Indexed for MEDLINE]
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