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Nat Rev Mol Cell Biol. 2008 Jul;9(7):569-74. doi: 10.1038/nrm2426. Epub 2008 Jun 4.

Extra-chromosomal elements and the evolution of cellular DNA replication machineries.

Author information

1
Adam T. McGeoch is at the MRC Cancer Cell Unit, Hutchison MRC Centre, Hills Road, Cambridge, CB2 0XZ, UK.

Abstract

DNA replication is fundamental to the propagation of cellular life. Remarkably, the bacterial replication machinery is distinct from that used by archaea and eukaryotes. In this article, we discuss the role that lateral gene transfer by extra-chromosomal elements might have had in shaping the replication machinery and even modulating the manner in which host cellular genomes are replicated.

PMID:
18523437
DOI:
10.1038/nrm2426
[Indexed for MEDLINE]

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