Format

Send to

Choose Destination
Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):415-9. doi: 10.1038/ncpendmet0844. Epub 2008 Jun 3.

Treatment of male infertility secondary to morbid obesity.

Author information

1
Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine, Seattle, WA 98195-6246, USA.

Abstract

BACKGROUND:

A 29-year-old man presented to a clinic with infertility and hypogonadism in the setting of morbid obesity. On presentation, he had notable gynecomastia and a low testicular volume. The patient's weight was 154 kg and his height was 168 cm (BMI 54.5 kg/m(2)). Before referral to the clinic, the patient had been treated with testosterone therapy for 4 months for hypogonadism. This treatment had caused his initially low sperm concentration to fall to undetectable levels.

INVESTIGATIONS:

Measurement of reproductive hormone levels, pituitary MRI, and semen analysis.

DIAGNOSIS:

Infertility secondary to hypogonadotropic hypogonadism and an elevated estrogen:testosterone ratio.

MANAGEMENT:

Treatment with an aromatase inhibitor, anastrozole, led to normalization of the patient's testosterone, luteinizing hormone and follicle-stimulating hormone levels, suppression of serum estradiol levels, and to normalization of spermatogenesis and fertility.

PMID:
18523426
PMCID:
PMC2664380
DOI:
10.1038/ncpendmet0844
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center