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Cell Metab. 2008 Jun;7(6):469-71. doi: 10.1016/j.cmet.2008.05.001.

Ezetimibe blocks internalization of the NPC1L1/cholesterol complex.

Author information

1
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. ta.yuan.chang@dartmouth.edu

Abstract

Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalization of the NPC1L1/cholesterol complex. The in vivo significance of these findings is discussed.

PMID:
18522826
DOI:
10.1016/j.cmet.2008.05.001
[Indexed for MEDLINE]
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