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Mol Oncol. 2007 Sep;1(2):196-204. doi: 10.1016/j.molonc.2007.05.007.

Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.

Author information

1
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA.

Abstract

Green tea catechins (GTCs) exert chemopreventive effects in many cancer models. Several studies implicate the DNA synthesis marker minichromosome maintenance protein 7 (MCM7) in prostate cancer progression, growth and invasion; representing a novel therapeutic target. In this study, we investigated the effect of GTCs on MCM7 expression in the transgenic adenocarcinoma mouse prostate model (TRAMP). DNA microarray, immunohistochemistry and western blot analysis showed that GTCs significantly suppressed MCM7 in the TRAMP mice treated with GTCs. Our study indicates that the cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by GTCs. Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role.

KEYWORDS:

chemoprevention; green tea catechins; minichromosome maintenance protein 7; prostate cancer; transgenic adenocarcinoma mouse prostate model

PMID:
18521193
PMCID:
PMC2408886
DOI:
10.1016/j.molonc.2007.05.007
[Indexed for MEDLINE]
Free PMC Article

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