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Nat Cell Biol. 2008 Jun;10(6):635-7. doi: 10.1038/ncb0608-635.

SUMO amplifies TGF-beta signalling.

Abstract

Transforming growth factor-beta (TGF-beta) stimulates phosphorylation of TGF-beta type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.

PMID:
18521068
DOI:
10.1038/ncb0608-635
[Indexed for MEDLINE]
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