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Neuroreport. 2008 Jun 11;19(9):951-5. doi: 10.1097/WNR.0b013e3283021ca9.

Oxytocin receptor-deficient mice developed late-onset obesity.

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1
Department of Physiology, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Abstract

The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr-/- mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis.

PMID:
18520999
DOI:
10.1097/WNR.0b013e3283021ca9
[Indexed for MEDLINE]
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