Format

Send to

Choose Destination
See comment in PubMed Commons below
Phys Rev Lett. 2008 Mar 21;100(11):118104. Epub 2008 Mar 21.

Nonequilibrium microtubule fluctuations in a model cytoskeleton.

Author information

1
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Abstract

Biological activity gives rise to nonequilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of embedded microtubules can be used to probe local stress fluctuations. We add myosin motors that drive the network out of equilibrium, resulting in an increased amplitude and modified time dependence of microtubule bending fluctuations. We show that this behavior results from steplike forces on the order of 10 pN driven by collective motor dynamics.

PMID:
18517833
DOI:
10.1103/PhysRevLett.100.118104
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Physical Society
    Loading ...
    Support Center